|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Xenografts morphologically mimicked the primary tumor and expressed S-100 protein and antigens associated with melanin synthesis (Melan-A, HMB45).
|
24946937 |
2014 |
|
Autism Spectrum Disorders
|
0.030 |
Biomarker
|
disease |
BEFREE |
While serum NSE, MBP, and S100B values cannot be considered as biomarkers for ASD, GFAP may be a biomarker and is suggested as a possible indicator of autism severity.
|
28711670 |
2017 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.030 |
Biomarker
|
disease |
BEFREE |
Whether these can be used in diabetes prevention needs to be carefully evaluated in animal models before use in future clinical assays.-Calviño-Sampedro, C., Gomez-Tourino, I., Cordero, O. J., Reche, P. A., Gómez-Perosanz, M., Sánchez-Trincado, J. L., Rodríguez, M. Á., Sueiro, A. M., Viñuela, J. E., Calviño, R. V. Naturally presented HLA class I-restricted epitopes from the neurotrophic factor S100-β are targets of the autoimmune response in type 1 diabetes.
|
30817223 |
2019 |
|
Diabetes Mellitus
|
0.070 |
Biomarker
|
group |
BEFREE |
Whether these can be used in diabetes prevention needs to be carefully evaluated in animal models before use in future clinical assays.-Calviño-Sampedro, C., Gomez-Tourino, I., Cordero, O. J., Reche, P. A., Gómez-Perosanz, M., Sánchez-Trincado, J. L., Rodríguez, M. Á., Sueiro, A. M., Viñuela, J. E., Calviño, R. V. Naturally presented HLA class I-restricted epitopes from the neurotrophic factor S100-β are targets of the autoimmune response in type 1 diabetes.
|
30817223 |
2019 |
|
Diabetes
|
0.050 |
Biomarker
|
disease |
BEFREE |
Whether these can be used in diabetes prevention needs to be carefully evaluated in animal models before use in future clinical assays.-Calviño-Sampedro, C., Gomez-Tourino, I., Cordero, O. J., Reche, P. A., Gómez-Perosanz, M., Sánchez-Trincado, J. L., Rodríguez, M. Á., Sueiro, A. M., Viñuela, J. E., Calviño, R. V. Naturally presented HLA class I-restricted epitopes from the neurotrophic factor S100-β are targets of the autoimmune response in type 1 diabetes.
|
30817223 |
2019 |
|
Immunologic Deficiency Syndromes
|
0.100 |
GeneticVariation
|
group |
BEFREE |
When simian immunodeficiency virus (SIV) deleted in the nef gene caused no disease in macaques and provided protection against wild-type SIV challenge, hopes were high that the removal of nef would convert a pathogenic immunodeficiency virus into a live attenuated vaccine.
|
15090885 |
2004 |
|
Immunologic Deficiency Syndromes
|
0.100 |
Biomarker
|
group |
BEFREE |
When inoculated into macaque monkeys, SHIV(MD14) carrying simian immunodeficiency virus-derived nef established significantly higher virus loads than did SHIV(MD1), which contains the HIV-1 nef gene.
|
9237701 |
1997 |
|
Rectal pouch
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Western blotting showed the expression levels of NSE, S-100, and C-kit were lower in the ARM group than that in the control group (P < .01).Histopathologic and IHC findings suggest that the distal rectal pouch has distinct defects in the neuromusculature.
|
30075558 |
2018 |
|
Anorectal Malformations
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Western blotting showed the expression levels of NSE, S-100, and C-kit were lower in the ARM group than that in the control group (P < .01).Histopathologic and IHC findings suggest that the distal rectal pouch has distinct defects in the neuromusculature.
|
30075558 |
2018 |
|
Autoimmune Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
We will show the expression patterns of S100-alarmins and correlation to disease activity in different forms of juvenile idiopathic arthritis, auto-inflammatory diseases, and systemic autoimmune disorders.
|
30828327 |
2019 |
|
Juvenile arthritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We will show the expression patterns of S100-alarmins and correlation to disease activity in different forms of juvenile idiopathic arthritis, auto-inflammatory diseases, and systemic autoimmune disorders.
|
30828327 |
2019 |
|
Juvenile rheumatoid arthritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We will show the expression patterns of S100-alarmins and correlation to disease activity in different forms of juvenile idiopathic arthritis, auto-inflammatory diseases, and systemic autoimmune disorders.
|
30828327 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We used comprehensive histologic subtyping to provide a semiquantitive assessment of histologic patterns in each tumor and performed immunohistochemical analyses including S100/vimentin/mammaglobin/DOG1.
|
25976476 |
2015 |
|
Parkinson Disease
|
0.070 |
Biomarker
|
disease |
BEFREE |
We undertook this study to establish the brain-specific S100B gene transgenic mice and investigate the role of S100B in the development of PD.
|
21376255 |
2011 |
|
Cardiovascular Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
We tested the hypothesis that human S100/calgranulin would accelerate cardiovascular disease in mice subjected to CKD.
|
24855059 |
2014 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We studied cytokine profile of cellular Th1 (IL-2, IL-12, IFN-γ) and humoral Th2 (IL-4, IL-10) immune response, vascular endothelial growth factor (VEGFA), transforming growth factor-β 2 (TGF-β 2), S100 protein (S100A1B and S100BB), adhesion molecule CD44 and serum cytokines β2-microglobulin to analyze different peripheral blood mononuclear cell subpopuations of patients treated with dendritic vaccines and/or cyclophosphamide in melanoma patients in the course of adjuvant treatment.
|
29849947 |
2018 |
|
Pneumonia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We speculate that the high levels of S100/calgranulins found in bronchoalveolar lavage fluid of asthmatics and of OVA-treated TG S100A12 mice do not significantly mediate pulmonary inflammation.
|
21418345 |
2011 |
|
Pneumonitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We speculate that the high levels of S100/calgranulins found in bronchoalveolar lavage fluid of asthmatics and of OVA-treated TG S100A12 mice do not significantly mediate pulmonary inflammation.
|
21418345 |
2011 |
|
Asthma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We speculate that the high levels of S100/calgranulins found in bronchoalveolar lavage fluid of asthmatics and of OVA-treated TG S100A12 mice do not significantly mediate pulmonary inflammation.
|
21418345 |
2011 |
|
Chronic Kidney Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
We speculate that fibroblast growth factor 23 produced by cardiac fibroblasts in response to cytokines may act in a paracrine manner to accelerate left ventricular hypertrophy and diastolic dysfunction in hBAC-S100 mice with CKD.
|
24855059 |
2014 |
|
Left Ventricular Hypertrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
We speculate that fibroblast growth factor 23 produced by cardiac fibroblasts in response to cytokines may act in a paracrine manner to accelerate left ventricular hypertrophy and diastolic dysfunction in hBAC-S100 mice with CKD.
|
24855059 |
2014 |
|
Neurological morbidity
|
0.010 |
Biomarker
|
disease |
BEFREE |
We sought to determine whether serum concentrations of neuron-specific enolase (NSE), myelin basic protein (MBP), and S100B, specific for neurons, oligodendrocytes, and glia, respectively, were predictive of neurological morbidity in critically ill children.
|
28612133 |
2018 |
|
Cerebral Hemorrhage
|
0.310 |
AlteredExpression
|
phenotype |
LHGDN |
We sought to determine plasma S100B level after acute (<24 hours) spontaneous intracerebral hemorrhage (ICH) and to study its relation with neurological outcome.
|
17008613 |
2006 |
|
Neurofibromatosis 1
|
0.040 |
Biomarker
|
disease |
BEFREE |
We showed that, although some neurofibromas include a subpopulation of S100B(+) /Nfn(-) cells consistent with clonal expansion of a Schwann cell progenitor that has lost function of both NF1 alleles, other neurofibromas do not show evidence of monoclonal proliferation of Schwann cells.
|
21674567 |
2011 |
|
neurofibroma
|
0.040 |
Biomarker
|
disease |
BEFREE |
We showed that, although some neurofibromas include a subpopulation of S100B(+) /Nfn(-) cells consistent with clonal expansion of a Schwann cell progenitor that has lost function of both NF1 alleles, other neurofibromas do not show evidence of monoclonal proliferation of Schwann cells.
|
21674567 |
2011 |